The thrill can kill: murder by methylation.
نویسنده
چکیده
Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. (p. 1319) show that a specific methylation occurs at the protein kinase Cepsilon (PKCepsilon) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKCepsilon, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.
منابع مشابه
علتشناسی قتلهای سریالی بر مبنای اختلالات شخصیتی
The serial murders for which the person able to kill multiple victims (and often accompanied by torture and persecution) and continues the murder to arrest, have criminological and psychological importance to single murder. Occurrence of serial murders is result of the external factors to internal and psychological. In fact, the location of important questions that explain why the some persons ...
متن کاملA comparison between men charged with domestic and nondomestic homicide.
Two hundred thirteen males charged with mur4er and who received pretrial psychiatric evaluations were divided into two groups of domestic and nondomestic homicide defendants. Demographics, developmental and family background, prior criminal records, victim characteristics, and psychiatric status at the time of the crime were used to compare these groups. Those who were charged with intrafamilia...
متن کاملپیشبینی شکست زودرس فیستولهای شریانی- وریدی بر مبنای معاینه در خاتمه جراحی
Background: For patients requiring chronic hemodialysis, the preferred site for vascular access is an autogenous arteriovenous fistula. Although a properly formed fistula is advantageous because it is less susceptible than other types of vascular accesses to infection and clot formation and can last longer than any other types of vascular access, AV fistula has a high rate of early failure that...
متن کاملSome Thoughts on the Psychological Roots of the Behavior of Serial Killers as Narcissists: an Object Relations Perspective
This article documents the definition and context of serial murder. The main theoretical framework adopted is object relations theories which have been particularly renowned for drawing close attention to the process and development of the early dyadic mother-infant relationship as a primary departure point for understanding both healthy and pathological psychic development. These theories have...
متن کاملEffect of Exposure to 900 MHz GSM Mobile Phone Radiofrequency Radiation on Estrogen Receptor Methylation Status in Colon Cells of Male Sprague Dawley Rats
Background: Over the past several years, the rapidly increasing use of mobile phones has raised global concerns about the biological effects of exposure to radiofrequency (RF) radiation. Numerous studies have shown that exposure to electromagnetic fields (EMFs) can be associated with effects on the nervous, endocrine, immune, cardiovascular, hematopoietic and ocular systems. In spite of genetic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Molecular pharmacology
دوره 71 5 شماره
صفحات -
تاریخ انتشار 2007